Melanotan-2 (MT-II)

Melanotan-2 (MT-II) is a synthetic cyclic heptapeptide analogue of α-MSH and a non-selective melanocortin receptor agonist (primarily MC1R, MC3R, MC4R and MC5R; minimal activity at MC2R). It is supplied as a high-purity lyophilized powder and used in research on melanogenesis/photobiology and central melanocortin pathways.

Product details

Amino Acid Sequence

Ac-Nle-cycloAsp−His−D−Phe−Arg−Trp−LysAsp-His-D-Phe-Arg-Trp-LysAsp−His−D−Phe−Arg−Trp−Lys-NH₂ (lactam bridge Asp²–Lys⁷)

Molecular Formula

C₅₀H₆₉N₁₅O₉

Molecular Weight

1024.2 g/mol

PubChem CID

92432

CAS Number

121062-08-6

Vial Size

3ml

Lyophilized powder, white/off-white color

Mechanism of action

Melanocortin receptor agonism (MC1R/3R/4R/5R)

MT-II activates melanocortin GPCRs; MC1R drives melanogenesis in skin, while MC3R/MC4R mediate central effects (e.g., sexual function, energy balance).

Melanogenesis & photobiology

MC1R stimulation increases eumelanin via cAMP/MITF/tyrosinase pathways; increased melanin is broadly photoprotective. (Context from α-MSH/melanocortin literature.)

Central neurosexual effects (MC4R-linked)

Studies with MT-II demonstrate erectogenic and pro-desire effects, consistent with central melanocortin pathway activation.

Storage & handling

Storage:

Store the lyophilized vial in a cool, dry area protected from direct sunlight.

Melanotan-2 (MT-II)