GLP-1 S

GLP-1 S is a synthetic analogue of the naturally occurring glucagon-like peptide-1 (GLP-1) hormone, supplied as a high-purity lyophilized powder. In in vitro studies, it’s widely used to investigate the biological basis of weight-loss mechanisms and to probe insulin-secretion and broader metabolic pathways.

Product details

Amino Acid Sequence

H-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys(Glu-C18 fatty acid)-Gln-Met-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser

Molecular Formula

C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight

4 114 g/mol

PubChem CID

56843331

CAS Number

910463-68-2

Vial Size

3ml

Lyophilized powder, white/off-white color

Mechanism of action

GLP-1 Receptor Agonism & Insulinotropic Effect

GLP-1 S binds the GLP-1 receptor on pancreatic β-cells, activating the Gαs–adenylate cyclase–cAMP–PKA cascade to enhance glucose-dependent insulin secretion and suppress glucagon release only when blood glucose is elevated.

Delayed Gastric Emptying & Reduced Gastrointestinal Motility

Activation of GLP-1 receptors in the gut and on vagal afferents slows gastric emptying and intestinal transit, reducing postprandial glucose excursions and contributing to satiety.

Central & Peripheral Appetite Suppression

GLP-1 S crosses the blood–brain barrier to engage GLP-1 receptors in hypothalamic nuclei and vagal pathways, enhancing satiety signals and dampening reward-driven feeding behaviors.

Storage & handling

Storage:

Store the lyophilized vial in a cool, dry area protected from direct sunlight. After reconstitution, refrigerate

Reconstitution:

Reconstitute with sterile, bacteriostatic water. Inject water down the vial wall; gently swirl until fully dissolved. Our standard vials can hold up to 3ml of BAC water

GLP-1 S