-30%
Tesamorelin - Image 1
Tesamorelin - Image 2
Click to enlarge
Tesamorelin
Tesamorelin - Image 2
GHK-CU
GHK-CU Original price was: $70.00.Current price is: $49.00.
Back to products
TB-500
TB-500 Original price was: $90.00.Current price is: $63.00.

Tesamorelin

Original price was: $100.00.Current price is: $70.00.

Tesamorelin is a synthetic 44-amino-acid analog of growth-hormone–releasing hormone (GHRH), supplied as a high-purity lyophilized powder. It is designed to activate the GHRH receptor on pituitary somatotrophs and is used in in vitro and preclinical research to study endogenous growth hormone release, GH-axis signaling, downstream IGF-1 activity, and metabolic pathway dynamics. Tesamorelin includes an N-terminal trans-3-hexenoyl modification that distinguishes it from native GHRH and improves peptide stability while preserving GHRH receptor activity. Unlike direct growth hormone, tesamorelin acts upstream by stimulating receptor-mediated GH release rather than supplying GH externally.

Description

Product details

Amino Acid Sequence

trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂

Molecular Formula:

C₂₂₁H₃₆₆N₇₂O₆₇S

Molecular Weight:

~5,135.9 g/mol

PubChem CID:

16137828

CAS Number:

218949-48-5

Vial Size:

3 mL

Contents:

Lyophilized powder, white/off-white color

Mechanism of action

GHRH / GRF Receptor Agonism

Tesamorelin acts as an analog of human growth-hormone–releasing hormone. It binds and stimulates GHRH / GRF receptors on pituitary somatotroph cells, activating the endogenous growth hormone release pathway. This receptor-level activity makes tesamorelin useful for studying pituitary GH secretion, GH pulse dynamics, and upstream control of the somatotropic axis.

Endogenous Growth Hormone Release

By stimulating the GHRH receptor, tesamorelin supports synthesis and pulsatile release of endogenous growth hormone from pituitary somatotroph cells.This distinguishes tesamorelin from recombinant growth hormone, which bypasses upstream hypothalamic-pituitary signaling and acts directly as the hormone itself.

Downstream IGF-1 Signaling

Growth hormone released from the pituitary can stimulate hepatic and peripheral production of insulin-like growth factor 1. IGF-1 is a major downstream mediator of GH-axis activity and is involved in anabolic signaling, tissue remodeling, and metabolic regulation.Tesamorelin is therefore useful in research models examining the relationship between GHRH receptor activation, GH release, IGF-1 response, and downstream endocrine signaling.

Storage & handling

Storage:

Store the lyophilized vial in a cool, dry area protected from direct sunlight.
Legal Disclaimer

All products on this site are for research and development, laboratory, or analytical use only; they are not for human consumption, medical, diagnostic, cosmetic, veterinary, or any other non-research application. The statements and products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Honest Peptide is not a compounding pharmacy or chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act, nor an outsourcing facility as defined under section 503B.

Related products

Select options This product has multiple variants. The options may be chosen on the product page

BAC Water

$12.00
-30%
Select options This product has multiple variants. The options may be chosen on the product page

BPC-157/TB-500

Original price was: $130.00.Current price is: $91.00.
-30%
Select options This product has multiple variants. The options may be chosen on the product page

CJC-1295 (No DAC)

Original price was: $50.00.Current price is: $35.00.
-30%
Select options This product has multiple variants. The options may be chosen on the product page

GLOW Blend

Original price was: $170.00.Current price is: $119.00.
-30%
Select options This product has multiple variants. The options may be chosen on the product page

GLP-1 S

Original price was: $85.50.Current price is: $60.00.
-30%
Select options This product has multiple variants. The options may be chosen on the product page

Ipamorelin

Original price was: $70.00.Current price is: $49.00.
-30%
Select options This product has multiple variants. The options may be chosen on the product page

Melanotan-2 (MT-II)

Original price was: $45.00.Current price is: $31.50.
-30%
Select options This product has multiple variants. The options may be chosen on the product page

MOTS-C

Original price was: $50.00.Current price is: $35.00.