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NAD+

Original price was: $160.00.Current price is: $112.00.

NAD⁺ (oxidized nicotinamide adenine dinucleotide) is a ubiquitous pyridine nucleotide coenzyme that accepts hydride ions in key metabolic pathways—glycolysis, the tricarboxylic acid cycle, and fatty-acid β-oxidation—to generate NADH for ATP production via oxidative phosphorylation. Beyond its redox role, NAD⁺ serves as an essential cosubstrate for NAD⁺-consuming enzymes such as sirtuin deacetylases and poly-ADP-ribose polymerases, thereby regulating gene expression, DNA-damage repair, and cellular stress responses. NAD⁺ availability also modulates mitochondrial biogenesis and metabolic homeostasis through SIRT1-PGC-1α signaling and impacts aging-related processes, as cellular NAD⁺ levels decline with age.

Description

Product details

Chemical Name:

Nicotinamide Adenine Dinucleotide (oxidized form)

Molecular Formula:

C₂₁H₂₇N₇O₁₄P₂

Molecular Weight:

663.43 g/mol

PubChem CID:

5883

CAS Number:

53-84-9

Synonyms:

NAD⁺, Coenzyme I

Vial Size:

10 mL

Contents:

Lyophilized powder, white/off-white color

Mechanism of action

Redox Coenzyme in Bioenergetics

NAD⁺ accepts hydride ions from key metabolic pathways—glycolysis, the tricarboxylic acid (TCA) cycle, and fatty‐acid β-oxidation—to form NADH, which then donates electrons to the mitochondrial electron‐transport chain for ATP synthesis via oxidative phosphorylation

Substrate for NAD⁺-Consuming Enzymes

Serves as an obligatory co-substrate for sirtuin deacetylases (e.g., SIRT1/3), poly-ADP-ribose polymerases (PARPs), and the NADase CD38, thereby regulating protein deacetylation, DNA-damage–response ADP-ribosylation, and calcium signaling.

Modulation of Gene Expression & Stress Responses

Through SIRT1-mediated deacetylation of transcriptional regulators (e.g., PGC-1α) and PARP-driven DNA repair, NAD⁺ levels fine-tune mitochondrial biogenesis, antioxidant defenses, and genomic stability under stress conditions.

Salvage Pathway & Mitochondrial Health

The NAMPT-dependent salvage pathway recycles nicotinamide into NAD⁺, sustaining intracellular pools; conversely, age-associated CD38 upregulation degrades NAD⁺, contributing to mitochondrial dysfunction.

Storage & handling

Storage:

Store the lyophilized vial in a cool, dry area protected from direct sunlight.
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